Article
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.
Nature genetics - 1 Oct 2025
Karczewski Konrad J, Gupta Rahul, Kanai Masahiro, Lu Wenhan, Tsuo Kristin, Wang Ying, Walters Raymond K, Turley Patrick, Callier Shawneequa, Shah Nirav N, Baya Nikolas, Palmer Duncan S, Goldstein Jacqueline I, Sarma Gopal, Solomonson Matthew, Cheng Nathan, Bryant Sam, Churchhouse Claire, Cusick Caroline M, Poterba Timothy, Compitello John, King Daniel, Zhou Wei, Seed Cotton, Finucane Hilary K, Daly Mark J, Neale Benjamin M, Atkinson Elizabeth G, Martin Alicia R
Abstract excerpt
Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits. However, people from diverse genetic ancestry groups are often excluded from association analyses due to concerns about population structure introducing false positive associations. Here we generate mixed model associations and meta-analyses across genetic...
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