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<i>Hhip</i> haploinsufficiency sensitizes mice to age-related emphysema

21 Jul 2016

Abstract excerpt

Genetic variants in Hedgehog interacting protein (HHIP) have consistently been associated with the susceptibility to develop chronic obstructive pulmonary disease and pulmonary function levels, including the forced expiratory volume in 1 s (FEV1), in general population samples by genome-wide association studies. However, in vivo evidence connecting Hhip to age-related FEV1 decline and emphysema development is...

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PMID: 27444019
DOI: 10.1073/pnas.1602342113

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