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Article

Influence of IL17A gene on the pathogenesis of immunoglobulin-A vasculitis.

Clinical and experimental rheumatology - 1 Jan 2000

López-Mejías Raquel, Genre Fernanda, Remuzgo-Martínez Sara, Pulito-Cueto Verónica, Sevilla-Pérez Belén, Llorca Javier, Ortego-Centeno Norberto, Mijares Verónica, Lera-Gómez Leticia, Leonardo Maria Teresa, Peñalba Ana, Cabero María Jesús, Martín-Penagos Luis, Miranda-Filloy José A, Navas Parejo Antonio, Sánchez Pérez Javier, de Argila Diego, Rubio Esteban, León Luque Manuel, Blanco-Madrigal Juan María, Galíndez-Agirregoikoa Eva, Martín Javier, Blanco Ricardo, Castañeda Santos, González-Gay Miguel A

Abstract excerpt

OBJECTIVES: Cytokines signaling pathway genes represent a key component of the genetic network implicated in the pathogenesis of immunoglobulin-A vasculitis (IgAV), an inflammatory vascular pathology. Interleukin (IL)17A is described as a genetic risk locus for some autoimmune diseases, such as giant cell arteritis and spondyloarthritis. Accordingly, we aimed to determine the potential influence of IL17A on the...

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PMID: 32242803

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