Article
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality.
Oncoimmunology - 1 Jan 2021
Bonte Sarah, de Munter Stijn, Billiet Lore, Goetgeluk Glenn, Ingels Joline, Jansen Hanne, Pille Melissa, de Cock Laurenz, Weening Karin, Taghon Tom, Leclercq Georges, Vandekerckhove Bart, Kerre Tessa
Abstract excerpt
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms' tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)- and TCR-redirected T cells, several clinical studies indicate that T cell subsets with a less-differentiated phenotype (e.g. stem cell memory T cells, TSCM) survive...
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