Article
In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2004
Doubrovina Ekaterina S, Doubrovin Mikhail M, Lee Sangyull, Shieh Jae-Hung, Heller Glen, Pamer Eric, O'Reilly Richard J
Abstract excerpt
The Wilms tumor protein (WT1) is overexpressed in most acute and chronic leukemias. To develop a practicable, clinically applicable approach for generation of WT1-specific T cells and to comparatively evaluate the immunogenicity of WT1 in normal individuals, we sensitized T cells from 13 HLA-A0201+ and 5 HLA-A2402+ donors with autologous EBV-transformed B cells or cytokine-activated monocytes, loaded with the...
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