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Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.

Psychiatric genetics - 1 Jun 2022

Chen Chia-Hsiang, Cheng Min-Chih, Hu Tsung-Ming, Ping Lieh-Yung, Kushima Itaru, Aleksic Branko

Abstract excerpt

OBJECTIVE: Studies showed that rare copy number variations (CNVs) encompassing the vasoactive intestinal peptide receptor 2 gene (VIPR2) were associated with schizophrenia, indicating VIPR2 is a risk gene for schizophrenia. We hypothesized that besides CNV, rare pathogenic single-nucleotide variant (SNV) or small insertion/deletion (Indel) of VIPR2 might be present in some patients and contribute to the...

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PMID: 35353798
DOI: 10.1097/YPG.0000000000000313

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