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Article

A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk.

American journal of human genetics - 2 Sept 2021

Marderstein Andrew R, Kulm Scott, Peng Cheng, Tamimi Rulla, Clark Andrew G, Elemento Olivier

Abstract excerpt

An individual's genetics can dramatically influence breast cancer (BC) risk. Although clinical measures for prevention do exist, non-invasive personalized measures for reducing BC risk are limited. Commonly used medications are a promising set of modifiable factors, but no previous study has explored whether a range of widely taken approved drugs modulate BC genetics. In this study, we describe a quantitative...

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Identifiers

PMID: 34363748
DOI: 10.1016/j.ajhg.2021.07.008
PMCID: PMC8456164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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