Article
Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.
Communications biology - 23 Jul 2021
Qu Hui-Qi, Qu Jingchun, Bradfield Jonathan, Marchand Luc, Glessner Joseph, Chang Xiao, March Michael, Li Jin, Connolly John J, Roizen Jeffrey D, Sleiman Patrick, Polychronakos Constantin, Hakonarson Hakon
Abstract excerpt
Type 1 diabetes (T1D) patients with low genetic risk scores (GRS) may be non-autoimmune or autoimmune mediated by other genetic loci. The T1D-GRS2 provides us an opportunity to look into the genetic architecture of these patients. A total of 18,949 European individuals were included in this study, including 6599 T1D cases and 12,323 controls. 957 (14.5%) T1D patients were identified with low GRS (GRS < 8.43). The...
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