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Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population.

Diabetes, obesity & metabolism - 1 Oct 2023

Liao Wen-Ling, Huang Yu-Nan, Chang Ya-Wen, Liu Ting-Yuan, Lu Hsing-Fang, Tiao Zih-Yu, Su Pen-Hua, Wang Chung-Hsing, Tsai Fuu-Jen

Abstract excerpt

AIMS: To analyse the genome-wide association study (GWAS) data of patients with type 1 diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk and age at diagnosis in the Taiwanese population. MATERIALS AND METHODS: We selected 610 patients with T1D and 2511 healthy individuals from an electronic medical record database of more than 300 000 individuals with genetic...

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PMID: 37455666
DOI: 10.1111/dom.15187

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