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Article

Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score.

Metabolism: clinical and experimental - 1 Jan 2021

Qu Jingchun, Qu Hui-Qi, Bradfield Jonathan P, Glessner Joseph T, Chang Xiao, Tian Lifeng, March Michael E, Roizen Jeffrey D, Sleiman Patrick M, Hakonarson Hakon

Abstract excerpt

Type 1 diabetes (T1D) is a heterogeneous disease. This study identified T1D cases with low polygenic risk score (PRS) to better represent T1D cases with less prominent autoimmune response (T1bD), and performed a gene-based association study to identify novel susceptibility loci in two independent cohorts, characterized by low PRS. The Notch ligand Delta-like 1 gene (DLL1) was identified with genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33157082
DOI: 10.1016/j.metabol.2020.154418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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