Article
Targeting the RB-pathway in Cancer Therapy
10 Feb 2010
Abstract excerpt
The RB-pathway, consisting of inhibitors and activators of cyclin-dependent kinases, the retinoblastoma tumor suppressor (RB), and the E2F-family of transcription factors, plays critical roles in the regulation of cell cycle progression and cell death. Components of this pathway, particularly p16Ink4a, cyclin D1, and RB, are frequently altered in sporadic human cancers to promote deregulated cellular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.