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Article

Next Generation Protein Structure Predictions and Genetic Variant Interpretation.

Journal of molecular biology - 1 Oct 2021

Diwan Gaurav D, Gonzalez-Sanchez Juan Carlos, Apic Gordana, Russell Robert B

Abstract excerpt

The need to make sense of the thousands of genetic variants uncovered every day in terms of pathology or biological mechanism is acute. Many insights into how genetic changes impact protein function can be gleaned if three-dimensional structures of the associated proteins are available. The availability of a highly accurate method of predicting structures from amino acid sequences (e.g. Alphafold2) is thus...

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PMID: 34358547
DOI: 10.1016/j.jmb.2021.167180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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