Article

Missense3D-PTMdb an interactive web resource to explore and visualize genetic variants and post-translational modifications sites (PTMs) using AlphaFold 3D models

2025-07-26

Abstract excerpt

Only a fraction of the >11 million missense variants identified in the human population has a known damaging or tolerated clinical impact. Post-translational modifications (PTMs), such as phosphorylation, glycosylation and ubiquitination, are key regulators of protein function and structure, and are critical for protein localisation, stability and interactions with other molecules. The ability of a protein to unde...

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Literature Corpus work: 1ccdc19b-8b9f-5735-ab2f-369a83b56903
DOI: 10.1101/2025.07.22.666170

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