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Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures.

Nature methods - 1 Oct 2024

Kwon Seulki, Safer Jordan, Nguyen Duyen T, Hoksza David, May Patrick, Arbesfeld Jeremy A, Rubin Alan F, Campbell Arthur J, Burgin Alex, Iqbal Sumaiya

Abstract excerpt

Recent advances in AI-based methods have revolutionized the field of structural biology. Concomitantly, high-throughput sequencing and functional genomics have generated genetic variants at an unprecedented scale. However, efficient tools and resources are needed to link disparate data types-to 'map' variants onto protein structures, to better understand how the variation causes disease, and thereby design...

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Identifiers

PMID: 39294369
DOI: 10.1038/s41592-024-02409-0
PMCID: PMC11466821

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