Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Missense3D-PTMdb: A Web Tool for Visualising and Exploring Human Genetic Variants and Post-translational Modification Sites Using AlphaFold Models.

Journal of molecular biology - 15 Sept 2026

Zhao Haotian, Pye Ryan, Walker Grace, Tran Wendy, Simmonds Olivia, Tsitsa Ifigenia, Islam Suhail, Hanna Gordon, David Alessia

Abstract excerpt

Only a fraction of the >11 million missense variants identified in humans has a known clinical significance. Post-translational modifications (PTMs), such as phosphorylation, glycosylation and ubiquitination, are key regulators of protein function and structure. PTMs depend on correct protein folding and the recognition and binding of enzymes to specific amino acid motifs near modification sites. AlphaFold models...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Protein
Share to Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Internet

Share to Mutation, Missense

Share to Protein Conformation

Share to Protein Folding

Share to Protein Processing, Post-Translational

Share to Software

Source

Identifiers

PMID: 41412489
DOI: 10.1016/j.jmb.2025.169595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Missense3D-PTMdb: A Web Tool for Visualising and Exploring Human Genetic Variants and Post-translational Modification Sites Using AlphaFold Models.PMID 41412489Read ↗

Missense3D-PTMdb an interactive web resource to explore and visualize genetic variants and post-translational modifications sites (PTMs) using AlphaFold 3D modelsSemantic proximity Read ↗

DeltaMut: An Integrative Database of AlphaFold2-Derived Missense Variant StructuresSemantic proximity Read ↗

GTExome: Modeling commonly expressed missense mutations in the human genomeSemantic proximity Read ↗

MSV3d: database of human MisSense Variants mapped to 3D protein structure.Semantic proximity Read ↗

HPMV: human protein mutation viewer - relating sequence mutations to protein sequence architecture and function changes.Semantic proximity Read ↗

Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effectsSemantic proximity Read ↗

DEOGEN2: prediction and interactive visualization of single amino acid variant deleteriousness in human proteins.Semantic proximity Read ↗

Insights into Disease-Associated Mutations in the Human Proteome through Protein Structural Analysis.Semantic proximity Read ↗

G23D: Online tool for mapping and visualization of genomic variants on 3D protein structures.Semantic proximity Read ↗

Evaluating variant effects in human proteins with ProtVarSemantic proximity Read ↗

ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteinsSemantic proximity Read ↗

Characterizing and explaining impact of disease-associated mutations in proteins without known structures or structural homologuesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.