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Article

Bioengineering a bacterial pathogen to assemble its own particulate vaccine capable of inducing cellular immunity.

Scientific reports - 2 Feb 2017

Lee Jason W, Parlane Natalie A, Wedlock D Neil, Rehm Bernd H A

Abstract excerpt

Many bacterial pathogens naturally form cellular inclusions. Here the immunogenicity of polyhydroxyalkanoate (PHA) inclusions and their use as particulate vaccines delivering a range of host derived antigens was assessed. Our study showed that PHA inclusions of pathogenic Pseudomonas aeruginosa are immunogenic mediating a specific cell-mediated immune response. Protein engineering of the PHA inclusion forming...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28150705
DOI: 10.1038/srep41607
PMCID: PMC5288705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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