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Article

Protective Immunity to<i>Pseudomonas aeruginosa</i>Induced with a Capsid-Modified Adenovirus Expressing<i>P. aeruginosa</i>OprF

18 Oct 2007

Abstract excerpt

This study focuses on the development of a new clinical vaccine candidate (AdOprF.RGD.Epi8) against Pseudomonas aeruginosa using an E1(-) E3(-) adenovirus (Ad) vector expressing OprF (AdOprF.RGD.Epi8) and modifications of the Ad genome providing two capsid changes: (i) modification of the Ad hexon gene to incorporate an immune-dominant OprF epitope (Epi8) into loop 1 of the hexon, enabling repeat administration...

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Identifiers

PMID: 17942539
DOI: 10.1128/jvi.01246-07

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