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Article

Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses

6 Aug 2021

Abstract excerpt

Cell lines are the mainstay in understanding the biology of COVID-19 infection but do not recapitulate many of the complexities of human infection. The use of human lung tissue is one solution for the study of such novel respiratory pathogens. We hypothesized that a cryopreserved bank of human lung tissue would allow for the ex vivo study of the interindividual heterogeneity of host response to SARS-CoV-2, thus...

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PMID: 34357881
DOI: 10.1172/jci.insight.148003

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