Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inborn errors of IKAROS and AIOLOS.

Current opinion in immunology - 1 Oct 2021

Yamashita Motoi, Morio Tomohiro

Abstract excerpt

IKAROS is a pioneer protein of the IKZF family of transcription factors that plays an essential role in lymphocyte development. Recently, inborn errors of IKAROS have been identified in patients with B cell deficiency and hypogammaglobulinemia, and these patients often present with recurrent sinopulmonary infection. Autoimmunity and hematologic malignancies are other characteristic complications seen in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Disease Management
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Ikaros Transcription Factor

Share to Immune System Diseases

Share to Infections

Source

Identifiers

PMID: 34265590
DOI: 10.1016/j.coi.2021.06.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inborn errors of IKAROS and AIOLOS.PMID 34265590Read ↗

Inborn errors of human IKAROS: LOF and GOF variants associated with primary immunodeficiencySemantic proximity Read ↗

AIOLOS-Associated Inborn Errors of Immunity.Semantic proximity Read ↗

IKAROS-Associated Diseases in 2020: Genotypes, Phenotypes, and Outcomes in Primary Immune Deficiency/Inborn Errors of Immunity.Semantic proximity Read ↗

AIOLOS Variants Causing Immunodeficiency in Human and MiceSemantic proximity Read ↗

Germline IKZF1 mutations and their impact on immunity: IKAROS-associated diseases and pathophysiology.Semantic proximity Read ↗

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.Semantic proximity Read ↗

NF-κB pathway variants in Iranian patients with inborn errors of immunity.Semantic proximity Read ↗

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene.Semantic proximity Read ↗

IKAROS Family Zinc Finger 1-Associated Diseases in Primary Immunodeficiency Patients.Semantic proximity Read ↗

Ikaros-Associated Diseases: From Mice to Humans and Back AgainSemantic proximity Read ↗

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.Semantic proximity Read ↗

The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.