Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma.

doi:10.1038/s41586-021-03747-1

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Article

Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma.

Nature - 1 Aug 2021

Berta Davide G, Kuisma Heli, Välimäki Niko, Räisänen Maritta, Jäntti Maija, Pasanen Annukka, Karhu Auli, Kaukomaa Jaana, Taira Aurora, Cajuso Tatiana, Nieminen Sanna, Penttinen Rosa-Maria, Ahonen Saija, Lehtonen Rainer, Mehine Miika, Vahteristo Pia, Jalkanen Jyrki, Sahu Biswajyoti, Ravantti Janne, Mäkinen Netta, Rajamäki Kristiina, Palin Kimmo, Taipale Jussi, Heikinheimo Oskari, Bützow Ralf, Kaasinen Eevi, Aaltonen Lauri A

Abstract excerpt

One in four women suffers from uterine leiomyomas (ULs)-benign tumours of the uterine wall, also known as uterine fibroids-at some point in premenopausal life. ULs can cause excessive bleeding, pain and infertility1, and are a common cause of hysterectomy2. They emerge through at least three distinct genetic drivers: mutations in MED12 or FH, or genomic rearrangement of HMGA23. Here we created genome-wide...

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PMID: 34349258
DOI: 10.1038/s41586-021-03747-1

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