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Article

Integrity of the P-site is probed during maturation of the 60S ribosomal subunit.

The Journal of cell biology - 11 Jun 2012

Bussiere Cyril, Hashem Yaser, Arora Sucheta, Frank Joachim, Johnson Arlen W

Abstract excerpt

Eukaryotic ribosomes are preassembled in the nucleus and mature in the cytoplasm. Release of the antiassociation factor Tif6 by the translocase-like guanosine triphosphatase Efl1 is a critical late maturation step. In this paper, we show that a loop of Rpl10 that embraces the P-site transfer ribonucleic acid was required for release of Tif6, 90 Å away. Mutations in this P-site loop blocked 60S maturation but were...

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Identifiers

PMID: 22689654
DOI: 10.1083/jcb.201112131
PMCID: PMC3373404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Integrity of the P-site is probed during maturation of the 60S ribosomal subunit.PMID 22689654Read ↗

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