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Article

Genetic Evidence on the Association of Interleukin (IL)-1-Mediated Chronic Inflammation with Airflow Obstruction: A Mendelian Randomization Study.

COPD - 1 Aug 2021

Yang Zhao, Schooling C Mary, Kwok Man Ki

Abstract excerpt

Preclinical studies suggest interleukin (IL)-1α/β is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, recent trials of anti-IL-1 therapies showed limited benefit for COPD. To clarify, we primarily examined total and direct effects of IL-1 and its receptors/coreceptors/receptor antagonists (IL-1/IL-1Rs) on airflow obstruction (AO) using Mendelian randomization (MR), and...

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Source

Identifiers

PMID: 34348529
DOI: 10.1080/15412555.2021.1955848

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