Article
Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease.
International immunopharmacology - 1 Sept 2022
Mi Jiarui, Liu Zhengye, Pei Shengduo, Wu Xia, Zhao Nan, Jiang Lingjuan, Zhang Zhenjie, Bai Xiaoyin
Abstract excerpt
BACKGROUND AND AIMS: IL-1 and IL-18 play important roles in intestine barrier integrity maintenance and inflammatory response. However, their net effects on the risk of IBD are still inconclusive. Here, we used Mendelian randomization (MR) approaches to investigate the causal associations of IL-18 and IL-1Ra (receptor antagonist) on the risks of IBD and subtypes. METHODS: For IL-18, both three-sample and...
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