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Article

Squamousness gain defines pancreatic ductal adenocarcinoma hepatic metastases phenotype, and gemcitabine response.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2021

Fraunhoffer Nicolas A, Abuelafia Analia M, Teyssedou Carlos, Chuluyan Eduardo, Bigonnet Martin, Palazzo Laurent, Gayet Odile, Nicolle Remy, Cros Jerome, Iovanna Juan, Dusetti Nelson

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a survival rate of less than 7%, mainly due to the hepatic metastatic spread. Despite the importance of understanding PDAC metastases, central questions remain concerning their biology and chemosensitivity. Moreover, the transcriptomic divergence between primary tumor (PT) and hepatic metastases (HM) has been poorly studied and without a...

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PMID: 34348180
DOI: 10.1016/j.ejca.2021.06.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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