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Article

The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella.

PLoS pathogens - 1 Aug 2021

Rytter Héloise, Jamet Anne, Ziveri Jason, Ramond Elodie, Coureuil Mathieu, Lagouge-Roussey Pauline, Euphrasie Daniel, Tros Fabiola, Goudin Nicolas, Chhuon Cerina, Nemazanyy Ivan, de Moraes Fabricio Edgar, Labate Carlos, Guerrera Ida Chiara, Charbit Alain

Abstract excerpt

Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic bacteria and thus represent potential targets for antibacterial strategies. Here we focused on the role of the pentose phosphate pathway (PPP) and its connections with other metabolic pathways in the pathophysiology of Francisella novicida. The involvement of the PPP in the intracellular life cycle of Francisella was first...

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Identifiers

PMID: 34339477
DOI: 10.1371/journal.ppat.1009326
PMCID: PMC8360588

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