Article
Amino acid deprivation and central carbon metabolism regulate the production of outer membrane vesicles and tubes by Francisella.
Molecular microbiology - 1 Feb 2018
Sampath Vinaya, McCaig William D, Thanassi David G
Abstract excerpt
Francisella tularensis is a highly virulent Gram-negative bacterial pathogen that causes the zoonotic disease tularemia. F. novicida, a model tularemia strain, produces spherical outer membrane vesicles (OMV), as well as novel tubular vesicles and extensions of the cell surface. These OMV and tubes (OMV/T) are produced in a regulated manner and contain known virulence factors. Mechanisms by which bacterial...
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