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Article

The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae.

Molecular microbiology - 1 Sept 2021

Shlla Bushra, Gazioglu Ozcan, Shafeeq Sulman, Manzoor Irfan, Kuipers Oscar P, Ulijasz Andrew, Hiller N Luisa, Andrew Peter W, Yesilkaya Hasan

Abstract excerpt

Rggs are a group of transcriptional regulators with diverse roles in metabolism and virulence. Here, we present work on the Rgg1518/SHP1518 quorum sensing system of Streptococcus pneumoniae. The activity of Rgg1518 is induced by its cognate peptide, SHP1518. In vitro analysis showed that the Rgg1518 system is active in conditions rich in galactose and mannose, key nutrients during nasopharyngeal colonization....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34328238
DOI: 10.1111/mmi.14788
PMCID: PMC8460608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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