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Contribution of the Rgg Transcription Regulator to Metabolism and Virulence ofStreptococcus suisSerotype 2

14 Dec 2010

Abstract excerpt

The Rgg-like regulators, a family of transcription factors commonly found in many Gram-positive bacteria, play multiple roles, especially in the control of pathogen virulence. Here, we report an rgg homologue from a Chinese isolate, 05ZYH33, of Streptococcus suis serotype 2 (SS2). Deletion of the rgg gene in SS2 increased its adhesion to Hep-2 cells and hemolytic activity in vitro. Significantly, inactivation of...

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PMID: 21149588
DOI: 10.1128/iai.00193-10

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