Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks.

doi:10.1073/pnas.062526099

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Article

Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2002

Smoot James C, Barbian Kent D, Van Gompel Jamie J, Smoot Laura M, Chaussee Michael S, Sylva Gail L, Sturdevant Daniel E, Ricklefs Stacy M, Porcella Stephen F, Parkins Larye D, Beres Stephen B, Campbell David S, Smith Todd M, Zhang Qing, Kapur Vivek, Daly Judy A, Veasy L George, Musser James M

Abstract excerpt

Acute rheumatic fever (ARF), a sequelae of group A Streptococcus (GAS) infection, is the most common cause of preventable childhood heart disease worldwide. The molecular basis of ARF and the subsequent rheumatic heart disease are poorly understood. Serotype M18 GAS strains have been associated for decades with ARF outbreaks in the U.S. As a first step toward gaining new insight into ARF pathogenesis, we...

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PMID: 11917108
DOI: 10.1073/pnas.062526099
PMCID: PMC123705

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