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Article

Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit.

Scientific reports - 29 Jul 2021

Katopodi Theodora, Petanidis Savvas, Domvri Kalliopi, Zarogoulidis Paul, Anestakis Doxakis, Charalampidis Charalampos, Tsavlis Drosos, Bai Chong, Huang Haidong, Freitag Lutz, Hohenforst-Schmidt Wolfgang, Matthaios Dimitris, Porpodis Konstantinos

Abstract excerpt

Intratumoral heterogeneity in lung cancer is essential for evasion of immune surveillance by tumor cells and establishment of immunosuppression. Gathering data reveal that circular RNAs (circRNAs), play a role in the pathogenesis and progression of lung cancer. Particularly Kras-driven circRNA signaling triggers infiltration of myeloid-associated tumor macrophages in lung tumor microenvironment thus establishing...

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Identifiers

PMID: 34326381
DOI: 10.1038/s41598-021-94671-x
PMCID: PMC8322174

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