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CircSOD2 polarizes macrophages towards the M1 phenotype to alleviate cisplatin resistance in gastric cancer cells by targeting the miR-1296/STAT1 axis.

Gene - 15 Dec 2023

Qu Bing, Liu Jiasheng, Peng Zhiyang, Xiao Zhe, Li Shijun, Wu Jianguo, Li Shengbo, Luo Jianfei

Abstract excerpt

Cisplatin is the first-line drug for gastric cancer (GC). Cisplatin resistance is the most important cause of poor prognosis for GC. Increasing evidence has identified the important role of macrophage polarization in chemoresistance. CircRNAs are newly discovered non-coding RNAs, characterized by covalently closed loops with high stability. Previous studies have reported a significant difference between circRNA...

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PMID: 37625563
DOI: 10.1016/j.gene.2023.147733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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