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Article

miR‐148a‐3p silences the CANX/MHC‐I pathway and impairs CD8 + T cell‐mediated immune attack in colorectal cancer

29 Jul 2021

Abstract excerpt

Abstract Nonresponse, or acquired resistance to immune checkpoint inhibitors in colorectal cancer (CRC) highlight the importance of finding potential tolerance mechanisms. Low expression of major histocompatibility complex, class I (MHC‐I) on the cell surface of the tumor is one of the main mechanisms of tumor escape from T‐cell recognition and destruction. In this study, we demonstrated that a high level of...

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PMID: 34324740
DOI: 10.1096/fj.202100235r

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