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Article

Natural genetic variation impacts complement inhibitory activity of PFam54 orthologs of Asian Borrelia bavariensis.

Scientific reports - 13 Mar 2026

Langhoff Luisa, Kapfer Paul, Röttgerding Florian, Margos Gabriele, Hepner Sabrina, Fingerle Volker, Sato Kozue, Kawabata Hiroki, Lin Yi-Pin, Brangulis Kalvis, Rollins Robert E, Kraiczy Peter

Abstract excerpt

European and Asian populations of Borrelia (B.) bavariensis, a causative agent of Lyme borreliosis, substantially differ in their infection dynamics. This is argued to be a byproduct of the unique demographic history of B. bavariensis in relation to colonizing Europe from a highly diverse, ancestral Asian population. Whether genetic factors related to human disease could be unique traits associated with the...

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Identifiers

PMID: 41826535
DOI: 10.1038/s41598-026-43598-2
PMCID: PMC12992818

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