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Article

Two Protochordate Genes Encode Pituitary Adenylate Cyclase-Activating Polypeptide and Related Family Members<sup>1</sup>

1 Jun 1997

Abstract excerpt

To address the origin of the glucagon superfamily, we isolated and sequenced the complementary DNA and partial gene that encode pituitary adenylate cyclase-activating polypeptide (PACAP) from a protochordate (tunicate), a sister group of the amphioxus and vertebrates, but one that evolved before the amphioxus. This is the first report of any superfamily member sequenced from an invertebrate. Transcription of the...

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Identifiers

PMID: 9165026
DOI: 10.1210/endo.138.6.5167

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