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Article

Structural divergence creates new functional features in alphavirus genomes

6 Jan 2018

Abstract excerpt

Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine encephalitis virus (VEEV), which causes encephalitis, have identified RNA structural elements that play key roles in replication and pathogenesis. However, a complete genomic...

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PMID: 29361131
DOI: 10.1093/nar/gky012

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