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Article

TP53 signature diagnostic system using multiplex reverse transcription-polymerase chain reaction system enables prediction of prognosis of breast cancer patients.

Breast cancer (Tokyo, Japan) - 1 Nov 2021

Takahashi Shin, Fukui Takafumi, Nomizu Tadashi, Kakugawa Yoichiro, Fujishima Fumisyoshi, Ishida Takanori, Ohuchi Noriaki, Ishioka Chikashi

Abstract excerpt

BACKGROUND: TP53 status based on TP53 signature, a gene expression profile to determine the presence or absence of TP53 mutation, is an independent prognostic factor of breast cancer. The purpose of this study was to develop a simple diagnostic system for TP53 signature status. METHODS: We developed a multiplex reverse transcription-polymerase chain reaction system to determine TP53 status. Based on this system,...

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Identifiers

PMID: 34302605
DOI: 10.1007/s12282-021-01250-z
PMCID: PMC8514380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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