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Article

Brain structural connectivity, anhedonia, and phenotypes of major depressive disorder: A structural equation model approach.

Human brain mapping - 15 Oct 2021

Pfarr Julia-Katharina, Brosch Katharina, Meller Tina, Ringwald Kai Gustav, Schmitt Simon, Stein Frederike, Meinert Susanne, Grotegerd Dominik, Thiel Katharina, Lemke Hannah, Winter Alexandra, Waltemate Lena, Hahn Tim, Opel Nils, Repple Jonathan, Bauer Jochen, Jansen Andreas, Dannlowski Udo, Krug Axel, Kircher Tilo, Nenadić Igor

Abstract excerpt

Aberrant brain structural connectivity in major depressive disorder (MDD) has been repeatedly reported, yet many previous studies lack integration of different features of MDD with structural connectivity in multivariate modeling approaches. In n = 595 MDD patients, we used structural equation modeling (SEM) to test the intercorrelations between anhedonia, anxiety, neuroticism, and cognitive control in one...

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PMID: 34302413
DOI: 10.1002/hbm.25600
PMCID: PMC8449111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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