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Article

Hypermetabolism in B-lymphocytes from malignant hyperthermia susceptible individuals.

Scientific reports - 20 Sept 2016

Hoppe Kerstin, Hack Guido, Lehmann-Horn Frank, Jurkat-Rott Karin, Wearing Scott, Zullo Alberto, Carsana Antonella, Klingler Werner

Abstract excerpt

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle metabolism which is characterized by generalized muscle rigidity, increased body temperature, rhabdomyolysis, and severe metabolic acidosis. The underlying mechanism of MH involves excessive Ca(2+) release in myotubes via the ryanodine receptor type 1 (RyR1). As RyR1 is also expressed in B-lymphocytes, this study investigated whether...

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Identifiers

PMID: 27646467
DOI: 10.1038/srep33372
PMCID: PMC5028841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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