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Article

High prevalence of tryptophan-truncated S quasispecies in treatment-naïve chronic hepatitis B patients.

The Journal of general virology - 1 Jul 2021

Dong Hui, Zhu Yongqiang, Shen Yan, Xie Shaoqing, He Yungang, Lu Lungen

Abstract excerpt

Hepatitis B virus surface antigen (HBsAg) encoded by the S gene is highly expressed during the replication cycle of hepatitis B virus (HBV). However, the frequent usage of tryptophan in HBsAg, which leads to a high cost of biosynthesis, is inconsistent with the high expression level of this protein. Tryptophan-truncated mutation of HBsAg, that is, a tryptophan to stop codon mutation resulting in truncated HBsAg,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34292864
DOI: 10.1099/jgv.0.001623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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