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Article

Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition.

Scientific reports - 21 Jul 2021

Brandes Nadav, Linial Nathan, Linial Michal

Abstract excerpt

The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Studies of genetic cancer predisposition typically identify significant genomic regions based on family-based cohorts or genome-wide association studies (GWAS). However, the results of such studies rarely provide biological insight or functional...

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Identifiers

PMID: 34290314
DOI: 10.1038/s41598-021-94252-y
PMCID: PMC8295298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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