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Article

WT1 inhibits AML cell proliferation in a p53-dependent manner.

Cell cycle (Georgetown, Tex.) - 1 Aug 2021

Yao Yiyun, Chai Xingxing, Gong Chen, Zou Lifang

Abstract excerpt

WT1 has been reported to function as an oncogene and a tumor suppressor in acute myeloid leukemia (AML). The molecular mechanisms have not yet been fully elucidated. Here, we report that p53, served as a tumor suppressor, plays a critical role in regulating the function of WT1 in AML. For details, we performed a meta-analysis on 1131 AML cases, showing that WT1 gene mutation and TP53 gene exhibited a mutually...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34288813
DOI: 10.1080/15384101.2021.1951938
PMCID: PMC8409780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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