Article
Association analysis and functional study of COL6A1 single nucleotide polymorphisms in thoracic ossification of the ligamentum flavum in the Chinese Han population.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Oct 2021
Qu Xiaochen, Hou Xiaofei, Chen Zhongqiang, Chen Guanghui, Fan Tianqi, Yang Xiaoxi
Abstract excerpt
PURPOSE: Genetic factors play a crucial role in thoracic ossification of the ligamentum flavum (TOLF). This study aimed to better understand the association between single nucleotide polymorphisms (SNP) in functional regions of the collagen VI, alpha 1 gene (COL6A1) and TOLF, and to confirm COL6A1 as a TOLF susceptibility gene. METHODS: Ten tag SNPs in COL6A1 were genotyped using the SNaPshot assay, and allele...
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