The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament.

doi:10.3892/mmr.2019.10846

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Article

The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament.

Molecular medicine reports - 1 Jan 2020

Wang Peng, Teng Ze, Liu Xiaoguang, Liu Xiao, Kong Chao, Lu Shibao

Abstract excerpt

Thoracic ossification of the posterior longitudinal ligament (T‑OPLL) is one of the most common factors that causes thoracic spinal stenosis, resulting in intractable myelopathy and radiculopathy. Our previous study reported that the rs201153092 polymorphism present in the collagen 6A1 (COL6A1) gene was a potentially pathogenic locus for the development of T‑OPLL. The present study aimed to determine whether the...

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PMID: 31939624
DOI: 10.3892/mmr.2019.10846
PMCID: PMC6896296

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