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Germline and Somatic mutations in postmenopausal breast cancer patients.

Clinics (Sao Paulo, Brazil) - 1 Jan 2000

Nagy Tauana Rodrigues, Maistro Simone, Encinas Giselly, Katayama Maria Lucia Hirata, Pereira Glaucia Fernanda de Lima, Gaburo-Júnior Nelson, Franco Lucas Augusto Moyses, Gouvêa Ana Carolina Ribeiro Chaves de, Diz Maria Del Pilar Estevez, Leite Luiz Antonio Senna, Folgueira Maria Aparecida Azevedo Koike

Abstract excerpt

OBJECTIVES: In breast cancer (BC) patients, the frequency of germline BRCA mutations (gBRCA) may vary according to the ethnic background, age, and family history of cancer. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is the second most common somatic mutated gene in BC; however, the association of mutations in both genes with cancer has not been thoroughly investigated. Thus,...

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Identifiers

PMID: 34287479
DOI: 10.6061/clinics/2021/e2837
PMCID: PMC8266163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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