Article
BRCA1, BRCA2, TP53, PIK3CA, PTEN and AKT1 genes mutations in Burkina Faso breast cancer patients: prevalence, spectrum and novel variant.
Molecular genetics and genomics : MGG - 1 Sept 2022
Ouedraogo Serge Yannick, Zoure Abdou Azaque, Zeye Moutanou Modeste Judes, Kiendrebeogo Touwendpoulimdé Isabelle, Zhou Xi, Sawadogo Alexis Yobi, Simpore Jacques, Chen Hanchun
Abstract excerpt
BRCA1 and BRCA2 are the two most commonly mutated tumor suppressor genes associated with hereditary breast cancer (BC). Also, mutations in TP53, PIK3CA, PTEN and AKT1 were observed at a high frequency in BC with their mutation spectrum exhibiting a subgroup particularity with enormous clinical significance in the prevention, classification and treatment of cancers. Unfortunately, the mutation spectrum of these...
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