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Article

IRE1α regulates skeletal muscle regeneration through myostatin mRNA decay

20 Jul 2021

Abstract excerpt

Skeletal muscle can undergo a regenerative process from injury or disease to preserve muscle mass and function, which is critically influenced by cellular stress responses. Inositol-requiring enzyme 1 (IRE1) is an ancient endoplasmic reticulum (ER) stress sensor and mediates a key branch of the unfolded protein response (UPR). In mammals, IRE1α is implicated in the homeostatic control of stress responses during...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 34283807
DOI: 10.1172/jci143737

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