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Article

Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank.

Translational psychiatry - 16 Jul 2021

Zhu Xingxing, Ward Joey, Cullen Breda, Lyall Donald M, Strawbridge Rona J, Lyall Laura M, Smith Daniel J

Abstract excerpt

Anhedonia is a core symptom of multiple psychiatric disorders and has been associated with alterations in brain structure. Genome-wide association studies suggest that anhedonia is heritable, with a polygenic architecture, but few studies have explored the association between genetic loading for anhedonia-indexed by polygenic risk scores for anhedonia (PRS-anhedonia)-and structural brain imaging phenotypes. Here,...

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PMID: 34282121
DOI: 10.1038/s41398-021-01522-4
PMCID: PMC8289859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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