Article
Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP).
Translational psychiatry - 13 Aug 2018
Ren Hongyan, Fabbri Chiara, Uher Rudolf, Rietschel Marcella, Mors Ole, Henigsberg Neven, Hauser Joanna, Zobel Astrid, Maier Wolfgang, Dernovsek Mojca Z, Souery Daniel, Cattaneo Annamaria, Breen Gerome, Craig Ian W, Farmer Anne E, McGuffin Peter, Lewis Cathryn M, Aitchison Katherine J
Abstract excerpt
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide association study (GWAS) followed by investigation of biological pathway enrichment using an anhedonia dimension for 759 patients with MDD in the GENDEP study. The GWAS identified 18 SNPs associated at...
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