Article
Protocol for a pharmacogenetic study of antidepressants: characterization of drug-metabolizing profiles of cytochromes CYP2D6 and CYP2C19 in a Sardinian population of patients with major depressive disorder.
Psychiatric genetics - 1 Oct 2021
Pinna Marco, Manchia Mirko, Pisanu Claudia, Pinna Federica, Paribello Pasquale, Carta Andrea, Meloni Anna, Conversano Claudio, Del Zompo Maria, Mola Francesco, Squassina Alessio, Carpiniello Bernardo
Abstract excerpt
The effectiveness of antidepressants shows high interindividual variability ranging from full symptomatologic remission to treatment-resistant depression. Many factors can determine the variation in the clinical response, but a fundamental role is played by genetic variation within the genes encoding for the enzymes most involved in the metabolism of antidepressant drugs: the CYP2D6 and CYP2C19 isoforms of the...
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