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Article

Do we need pharmacogenetics to personalize antidepressant therapy?

Cellular and molecular life sciences : CMLS - 1 Sept 2013

Lanni Cristina, Racchi Marco, Govoni Stefano

Abstract excerpt

This review examines the role of drug metabolism and drug target polymorphism in determining the clinical response to antidepressants. Even though antidepressants are the most effective available treatment for depressive disorders, there is still substantial need for improvement due to the slow onset of appreciable clinical improvement and the association with side effects. Moreover, a substantial group of...

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Share to Antidepressive Agents
Share to Aryl Hydrocarbon Hydroxylases
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP2D6

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Share to Tryptophan Hydroxylase

Source

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Identifiers

PMID: 23272319
DOI: 10.1007/s00018-012-1237-5
PMCID: PMC11113225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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